Vascepa (Icosapent Ethyl) for cardiovascular disease

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Vascepa is indicated for reducing the risk of myocardial infarction, stroke, coronary revascularization and unstable angina requiring hospitalization in adult patients.

Pearl of the day medication: Vascepa (icosapent ethyl)

Indication: Vascepa is an ethyl ester of (EPA) indicated as an adjunct to maximally tolerated statin therapy to reduce the risk of myocardial infarction, stroke, coronary revascularization and unstable angina requiring hospitalization in patients. adult patients with high triglyceride (TG) levels (≥ 150 mg / dL) and established cardiovascular (CV) disease or diabetes mellitus and at least 2 additional risk factors for CV disease.

Overview:

  • Dosage: The daily dose of Vascepa is 4 grams per day as four 0.5 gram capsules twice daily with food or two 1 gram capsules twice daily with food.
  • Dosage form: Capsules in 0.5 gram and 1 gram
  • Contraindication: Vascepa is contraindicated in patients with known hypersensitivity (eg, anaphylactic reaction) to Vascepa or any of its ingredients.
  • Adverse events: Common side effects are musculoskeletal pain, peripheral edema, constipation, gout and atrial fibrillation.
  • Drugs interactions: Increased risk of bleeding with anticoagulants and antiplatelet agents — some published studies with omega-3 fatty acids have shown an increase in bleeding time.
  • Action mechanism: Studies suggest that EPA reduces the synthesis and / or secretion of hepatic very low density lipoprotein (VLDL-TG) triglycerides and improves clearance of TG from circulating VLDL particles.
  • Maker: Amarin

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